Abstract
A simple, accurate, precise method was developed for the estimation of Bempedoic acid and Ezetimibe in the tablet dosage form of Bempedoic acid and Ezetimibe. Optimized separation was achieved on an Ascentis C18 150x 4.6mm, 5 using mobile phase composition of phosphate buffer pH 4.0 and acetonitrile in the ratio of 700 mL:300 mL (v/v) at a flow rate of 1.0 mL/min; the injection volume is 10 μL and run time 6 minutes in isocratic elution. UV detection was carried out at a wavelength of 230 nm. The temperature was maintained at 30°C. Wellresolved peaks were observed with high numbers of theoretical plates, lower tailing factor and reproducible relative retention time. The method was validated and all the validation parameters were found to be within the acceptable limits.
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