Abstract
Increased levels of leptin are common features of obesity and type 2 diabetes, reflecting leptin resistance. Reduced circulating natriuretic peptide (NP) concentrations are independently associated with type 2 diabetes and obesity, while increased natriuretic peptide levels appear to be protective. Observational studies suggest that high NP levels are associated with reduced leptin concentrations. Whether or not this is a causal relationship is unknown.
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