A novel electrochemical sensor based on molecularly imprinted polymer with binary functional monomers at Fe-doped porous carbon decorated Au electrode for the sensitive detection of lomefloxacin

Abstract

A novel molecularly imprinted polymer (MIP) electrochemical sensor for the sensitive detection of lomefloxacin (LFX) was developed for the first time. For this, Fe-doped porous carbon (Fe-PC) was firstly synthesized and then used to modify the Au electrode. MIP film with binary functional monomers was fabricated on the Fe-PC modified Au electrode surface by electropolymerization, with LFX as template molecule, o-phenylenediamine (o-PD) and β-cyclodextrin (β-CD) as binary functional monomers. The results showed that the developed sensor exhibited high selectivity and sensitivity in detection of LFX, which was attributed to the large specific surface area, rich porosity and good catalytic property of Fe-PC, as well as high selectivity and affinity of MIP prepared with binary functional monomers. Under the optimal conditions, the current response was linear to the concentration of LFX ranging from 1 to 120 nM, with a detection limit of 0.2 nM (S/N = 3). Moreover, the developed sensor showed good reproducibility and stability toward LFX detection, and it was applied to detect LFX in water and milk samples with good recoveries ranging from 86.6% to 105.0%.