A novel electrochemical sensor based on Cu(Ⅱ) metal organic framework for the determination of metformin

Abstract

Herein, a novel, simple prepared and robust electrochemical sensor based on the copper-containing metal organic framework (CuBTC) has been developed for the determination of metformin (MET), a first-line drug for type 2 diabetes mellitus. CuBTC was synthesized by hydrothermal method. The morphology and structure of CuBTC were characterized by scanning electron microscopy, X-ray powder diffraction and infrared spectroscopy. The electrochemical behavior of MET at the glassy carbon electrode modified with CuBTC/Nafion mixture was deeply explored by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The electrochemical studies showed that CuBTC had excellent electrocatalytic ability towards the redox reaction of MET. Under the optimal conditions, the linear range of MET on the modified electrode was 0.5–280 μmol/L, and the detection limit was 0.19 μmol/L. Additionally, the proposed sensor exhibited good long-time stability, reproducibility and selectivity, which was successfully applied to detect MET in tablets, serum and urine samples.