Abstract
Cupric chloride dihydrate catalyzes the three-component Biginelli condensation between an aldehyde, a b-ketoester and urea or thiourea under microwave irradiation in the absence of solvent to yield various substituted 3,4-dihydropyrimidin-2(1H)-ones. The reaction is also effective when performed at room temperature in acetonitrile or at 100 °C in a solvent free approach, without any side reactions as observed by Biginelli and others.
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