Abstract
Background & Aim Umbilical cord-derived MSC showed significant angiogenic potential via paracrine and direct cell-to-cell support to the vasculature. Endothelial progenitor cells (EPC) have the potential to develop vascular structures while maintaining paracrine properties following ischemic injury. Hypothesis A combination therapy of first trimester umbilical cord perivascular cells (FTM HUCPVC) with rat EPC will promote significant angiogenesis, cardiomyocyte survival and lead to functional cardiac recovery after MI. Methods, Results & Conclusion Methods MI was induced by LAD ligation on 8-week-old Foxrnu rats. 1 week later, rats with notable decrease ( Results 5-days after injection, exclusively G4 animals showed significant cardiac recovery, improved EF and FS compared to G1-G2-G3 (p Conclusions Our results indicate the superior potential of FTM HUCPVC - EPC combination cell therapy compared to single-cell-type treatments for myocardial regeneration and cardiac function recovery after MI.
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