A Novel Approach Towards Nanosuspension

Abstract

Many of the newly invented drugs are poorly soluble and they create major problems during formulation and shows poor bioavailability. The problem is even more complex for drugs which belong to BCS class 2 category. To overcome these problems nanotechnology is used to improve the solubility as well as bioavailability of poorly soluble drugs. The reduction of drug particles into submicron range leads to a significant increase in dissolution rate and therefore enhances bioavailability. Nanosuspension contains submicron colloidal dispersion of the pharmaceutical active ingredient particles in a liquid phase stabilized by surfactant. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogent and cryoprotectant. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions not only solves the problem of poor solubility and bioavailability but also alter the pharmacokinetics of the drug and thus improving safety and efficacy. This review article mainly focuses on preparation of nanolsuspensions by various techniques with their advantages and disadvantages, formulation consideration, characterization and their applications in drug delivery.