Abstract

PurposeTo develop a novel approach to accurately verify patient set up in proton radiotherapy, especially for the verification of the nozzle – body surface air gap and source-to-skin distance (SSD), the consistency and accuracy of which is extremely important in proton treatment.MethodsPatient body surfaces can be captured and monitored with the optical surface imaging system during radiation treatment for improved intrafraction accuracy. An in-house software package was developed to reconstruct the patient body surface in the treatment position from the optical surface imaging reference capture and to calculate the corresponding nozzle – body surface air gap and SSD. To validate this method, a mannequin was scanned on a CT simulator and proton plans were generated for a Mevion S250 Proton machine with 20 gantry/couch angle combinations, as well as two different snout sizes, in the Varian Eclipse Treatment Planning Systems (TPS). The surface generated in the TPS from the CT scan was imported into the optical imaging system as an RT Structure for the purpose of validating and establishing a benchmark for ground truth comparison. The optical imaging surface reference capture was acquired at the treatment setup position after orthogonal kV imaging to confirm the positioning. The air gaps and SSDs calculated with the developed method from the surface captured at the treatment setup position (VRT surface) and the CT based surface imported from the TPS were compared to those calculated in TPS. The same approach was also applied to 14 clinical treatment fields for 10 patients to further validate the methodology.ResultsThe air gaps and SSDs calculated from our program agreed well with the corresponding values derived from the TPS. For the phantom results, using the CT surface, the absolute differences in the air gap were 0.45 mm ± 0.33 mm for the small snout, and 0.51 mm ± 0.49 mm for the large snout, and the absolute differences in SSD were 0.68 mm ± 0.42 mm regardless of snout size. Using the VRT surface, the absolute differences in air gap were 1.17 mm ± 1.17 mm and 2.1 mm ± 3.09 mm for the small and large snouts, respectively, and the absolute differences in SSD were 0.81 mm ± 0.45 mm. Similarly, for patient data, using the CT surface, the absolute differences in air gap were 0.42 mm ± 0.49 mm, and the absolute differences in SSD were 1.92 mm ± 1.4 mm. Using the VRT surface, the absolute differences in the air gap were 2.35 mm ± 2.3 mm, and the absolute differences in SSD were 2.7 mm ± 2.17 mm.ConclusionThese results showed the feasibility and robustness of using an optical surface imaging approach to conveniently determine the air gap and SSD in proton treatment, providing an accurate and efficient way to confirm the target depth at treatment.

Highlights

  • Wilson theorized that fast protons could be used for treating deep-seated tumors while sparing adjacent normal tissues due to the unique physical properties in 1946 [1], and according to the PTCOG website as of December 2017, more than 170,000 patients worldwide have been treated with proton therapy

  • While the range of proton beam is set in treatment planning system (TPS), any change in the radiological equivalent depth during treatment could potentially cause undercoverage of the target, or shifting of high doses to the normal tissues

  • The physical depth change will be reflected in source-to-skin distance (SSD) change after alignment of target to machine isocenter, keeping source-axis distance (SAD) the same

Read more

Summary

Introduction

Wilson theorized that fast protons could be used for treating deep-seated tumors while sparing adjacent normal tissues due to the unique physical properties in 1946 [1], and according to the PTCOG website (https:// www.ptcog.ch) as of December 2017, more than 170,000 patients worldwide have been treated with proton therapy. Volumetric imaging, using cone-beam computed tomography (CBCT) or CT-on-rails, and 2D orthogonal kilovoltage (kV) imaging are the available options for image guidance in proton therapy to ensure patient position before treatment [5,6,7]. These IGRT tools are very useful in positioning the target volume correctly relative to the treatment machine, it is critically important to acquire the target depth information to ensure correct coverage. The current approach to verify the air gap at the time of treatment is to manually measure the closest distance from the end of compensator to patient surface inside the snout area with a ruler, which can be subjective and inefficient

Objectives
Methods
Results
Discussion
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call