Abstract
Iron deficiency anaemia is the most common nutritional deficiency disorder, contributing to 50 percent of all the anaemias in the world. Dietary changes alone are insufficient for the correction and management of iron deficiency anaemia. Hence, iron supplementation is necessary. Conventional oral iron therapy is limited in many patients because of dose dependent side effects, insufficient absorption, lack of compliance and limitation in various inflammatory conditions. Liposomal iron is a technologically designed, innovative form of iron which due to its differential delivery system ensures higher absorption and bioavailability, greater tolerability and least gastro-intestinal side effects unlike conventional oral iron preparations. This review provides a critical discussion and a comprehensive view based on the author’s review of the medical literature concerning the technology of liposomal iron preparation, mechanism of its absorption, its advantage over conventional iron preparations and clinical evidence on its usage in iron deficient states in pregnancy and certain inflammatory conditions.
Highlights
Iron is amongst the most essential mineral required for human life and is abundantly available in the earth’s crust
This review provides a critical discussion and a comprehensive view based on the author’s review of the medical literature concerning the technology of liposomal iron preparation, mechanism of its absorption, its advantage over conventional iron preparations and clinical evidence on its usage in iron deficient states in pregnancy and certain inflammatory conditions
30 post-menopausal females with iron deficiency anaemia (Haemoglobin, Hb < 11.5 g/dL) who were already been treated with other iron supplements and experiencing side effects, were treated with liposomal iron supplement
Summary
Iron is amongst the most essential mineral required for human life and is abundantly available in the earth’s crust. Iron is vital for several bodily functions including haemoglobin synthesis, transport of oxygen throughout the body and catalytic activity of various enzymes. Nutritional interest in iron mainly involved its role in haemoglobin synthesis and oxygen transport in the body. As per World Health Organization (WHO) estimates, approximately two billion people are anaemic worldwide and around 50% of all anaemias are attributed to iron deficiency [3]. It occurs at all stages of the life cycle but is more prevalent in pregnant women and young children [4]. We discuss in detail about the role of liposomal iron in the management of iron deficiency anaemia (IDA)
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