Abstract
d-Serine is an endogenous modulator of brain N-methyl- d-aspartate receptors. This study investigates serine transport in brain synaptosomal fractions. Saturable, temperature-dependent uptake of both d- and l-[ 3H]serine was observed. Alanine was only partially effective in blocking transport, arguing against involvement of system ASC. Inhibitors of the systems A, L and GLY were also ineffective. Saturation studies suggested a submillimolar K m for both d- and l-serine. These data suggest the presence of a novel serine transport system in rodent synaptosomes.
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