Abstract
High resolution is a common demand of many imaging technologies currently used for small animals. Computed tomography, magnetic resonance imaging, and ultrasound imaging are highly developed imaging techniques providing submillimeter spatial resolutions. Along with single-photon emission computed tomography, positron emission tomography (PET) is the most sensitive molecular imaging modality for in vivo imaging. This chapter introduces the basics of high-resolution small animal PET with a strong focus on multiwire proportional chamber PET. The four-detector high-density avalanche chamber PET will be highlighted as a high-resolution PET system for small animals and applications will be given in cardiology, oncology, and neurology.
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