Abstract
The aim of this study is to develop polymeric chemisorbents with a high density of ninhydrin groups, able to covalently bind urea under physiological conditions and thus potentially suitable for use in a wearable artificial kidney. Macroporous beads are prepared by suspension polymerization of 5-vinyl-1-indanone (vinylindanone) using a 90:10 (v/v) mixture of toluene and nitrobenzene as a porogen. The indanone groups are subsequently oxidized in a one-step procedure into ninhydrin groups. Their urea absorption kinetics are evaluated under both static and dynamic conditions at 37 °C in simulated dialysate (urea in phosphate buffered saline). Under static conditions and at a 1:1 molar ratio of ninhydrin: urea the sorbent beads remove ≈0.6-0.7 mmol g-1 and under dynamic conditions and at a 2:1 molar excess of ninhydrin ≈0.6 mmol urea g-1 sorbent in 8 h at 37 °C, which is a step toward a wearable artificial kidney.
Highlights
The aim of this study is to develop polymeric chemisorbents with a high patients, wearable artificial kidney devices density of ninhydrin groups, able to covalently bind urea under physiological conditions and potentially suitable for use in a wearable artificial kidney
The aim of this study is to design, prepare, and characterize macroporous sorbent beads with a high density of ninhydrin groups obtained by suspension polymerization of vinylindanone, followed by a one-step oxidation of the indanone groups into ninhydrin groups
The reaction conditions were optimized until almost quantitative conversion (Section S2, Supporting Information) and vinylindanone was isolated after filtration over a silica plug in a 85% yield
Summary
The aim of this study is to develop polymeric chemisorbents with a high patients, wearable artificial kidney devices density of ninhydrin groups, able to covalently bind urea under physiological conditions and potentially suitable for use in a wearable artificial kidney. The indanone groups are subsequently is a major challenge in the realization of oxidized in a one-step procedure into ninhydrin groups Their urea absorption such a wearable dialysis device,[5,6] since kinetics are evaluated under both static and dynamic conditions at 37 °C in simulated dialysate (urea in phosphate buffered saline). Chemisorption of urea by a sorbent, that is able to form fering from end-stage kidney disease These patients undergo irreversible covalent bonds with urea at 37 °C, seems an attracdialysis sessions in the hospital or dialysis centers during which tive strategy as 1) high urea binding capacities (BC) have been these waste solutes diffuse over a nanoporous membrane, reported[13,18,19,20] and 2) no potentially harmful side products effectively removing these waste solutes from their body.[1] are formed.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
