Abstract
The hydrothermal reactions of bis{6-{5-methyl-1H,7H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one}}methane (L) and Zn(NO3)2·6H2O at 180 ℃ afforded a novel Zn(II) coordination polymer (CP), that is, {[Zn2(L)(µ2-O)2]·3H2O}n (1), which further characterized via Single crystal X-ray diffraction (SCXRD), elemental analysis (EA), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA). Besides, this CP reveals strong luminescence that may be caused by the charge transfer within the ligand. In biological study, the new compound was evaluated for its protective effect on chondrocytes. This compound significantly up-regulated GPX4 and down-regulated HO-1 mRNA levels, thereby inhibiting iron death in chondrocytes.
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