Abstract
A phytochemical study of the ethanolic extract of Ligularia przewalskii (Maxim.) Diels led to the isolation of two new terpenoids, (1βH,3βH)-epoxy-olean-13(18)-ene-3α,2-olide (1) and 8β-hydroxy-(10βH)-14β-methyl-6α-angeloyloxy eremophil-7(11)-en-8α,12-olide-15α-oic acid (2), along with 22 known compounds (3–24), of which compounds 3–13 were isolated from this plant for the first time. The structures of these compounds were established on the basis of spectroscopic methods. Compounds 1–2 were evaluated for their in vitro anti-proliferative activities against Hep-G2 and MCF-7 tumour cell lines. Compound 1 exhibited strong inhibitory activity against Hep-G2 cell growth, in contrast to moderate cytotoxic activity against MCF-7 cells. Although compound 2 showed strong inhibitory activity against MCF-7 cell growth, it appeared to have modest activity against Hep-G2 cells.
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