Abstract
A new lignan glycoside, tianshanoside A (1), together with a known phenylpropanoid glycoside, syringin (2) and two known lignan glycosides, picraquassioside C (3), and aketrilignoside B (4), were isolated from the whole plant of Viola tianshanica Maxim. The structure of the new compound was elucidated by extensive NMR (1H, 13C, COSY, HSQC, HMBC and ROESY) and high resolution mass spectrometry analysis. The three lignans 1, 3, and 4 did not exhibit significant cytotoxicity against human gastric cancer Ags cells or HepG2 liver cancer cells. This is the first report of the isolation of a lignan skeleton from the genus Viola L.
Highlights
Viola tianshanica Maxim (Violaceae) is a perennial herb widely distributed in Central Asia, especially in the Xinjiang Uygur Autonomous Region (XUAR) of China [1]
It is used in XUAR as a substitute for Viola yedoensis
Repeated column chromatography of the ethyl acetate fraction of the ethanolic extract of V. tianshanica led to the isolation of a new tetrahydrofuran lignan diglycoside (1)
Summary
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China Key Laboratory of Modern Chinese Preparation, Jiangxi University of Traditional Chinese Medicine, Ministry of Education of China, Nanchang 330004, China Received: 11 September 2013; in revised form: 10 October 2013 / Accepted: 18 October 2013 /
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