A new strategy for the synthesis of the core trisaccharide of asparagine-linked sugar chains

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The core trisaccharide common to all asparagine-linked glycoprotein oligosaccharides was synthesized using two novel processes: 1) regioselective acetylation using lipase, and 2) inversion of the C-2 hydroxyl group of the glucose residue in a glucosyl chitobiose derivative to produce the corresponding mannosyl chitobiose derivative.