Abstract
ABSTRACT Vaccination is generally known as the most effective strategy for controlling infectious diseases. However, the traditional vaccine approaches are incapable of preventing emerging infectious diseases as well as antigenically hypervariable pathogens that are still a main threat for world health. Recent advances in computational approaches developed for epitope identification and in silico analysis have paved the way for the design of epitope-based vaccines against these kinds of pathogens. The aim of these novel vaccines is to induce immune responses in a more effective way than the conventional vaccines. In this review, we describe the principles of epitope-based vaccine design, along with the application of these approaches in design and development of high density multiepitope construct as the first epitope-based vaccine candidate against hepatitis E virus. Keywords: Epitope-based vaccine; Multiepitope construct; High epitope density; In silico vaccine design; Epitope selection; Optimization; Hepatitis E virus; Immunity
Published Version
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