A NEW SERIES OF 1,3,4-THIADIAZOLE SUBSTITUTED AZETIDINONE AND THIAZOLIDINONE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY

Abstract

The new series of 2-({[5-(3-chloro-2-oxo-4-substituted-phenylazetidin-1-yl)-1,3,4-thiadiazol-2- yl]methyl}amino)benzoic acid (13-20) and 2-({[5-(4-oxo-2- substituted-phenyl-1,3-thiazolidin-3-yl)- 1,3,4- thiadiazol-2-yl]methyl}amino)benzoic acid (21-28) have been synthesized from 2-[({5-[(benzylideneamino]- 1,3,4- thiadiazol-2-yl }methyl)amino]-benzoic acid (5-12). All these synthesized compounds were tested for their antimicrobial activity and established by spectroscopic data, and elemental analyses.