Abstract
The construction of a benzo-fused tetracyclic sulfonamide, followed by its low-valent titanium-based reduction and subsequent conversion to racemic crinane is reported. The synthesis of the tetracyclic sulfonamide features a sulfonyl templated, regio- and diastereoselective intramolecular Heck reaction, which installs an all-carbon quaternary centre. Thereafter, a low-valent titanium reduction removes the sulfonyl group, liberating a 3-aryloctahydroindole. A Pictet-Spengler reaction then generates the targeted ethano-bridged phenanthridine core structure of the crinan alkaloids.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
