Abstract
Evidence indicates that Na2 eosin Y-derived photoexcited states functions as a direct hydrogen atom transfer (HAT) catalyst to synthesize dihydropyrano[2,3-c]pyrazole scaffolds photochemically via four-condensation domino reaction of tandem Knoevenagel-Michael cyclocondensation reaction ethyl acetoacetate, hydrazine hydrate, aryl aldehyde derivatives and malononitrile via visible light-mediated in aqueous ethanol at ambient temperature under air atmosphere. This study paves the new role for further the use of a metal-free organic dye with commercial availability and inexpensiveness, Na2 eosin Y in photochemical synthesis with use of the lowest amount of catalyst, excellent yields, time-saving aspects of the reaction and high atom economy. Notably, this cyclization is also runnable on the gram scale, which highlights the potentiality of using this reaction in industrial uses.
Published Version
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