Abstract
Small GTPases related to Ras influence fundamental cellular processes such as cell differentiation, organization of the cytoskeleton, and vesicular transport. For proper function, Ras and its cousins have to be anchored to the membrane by isoprenoid residues. These posttranslational modifications are prevented by depletion of mevalonate, the precursor of isoprenoids and cholesterol. The effects of inhibition of isoprenylation on protein function have already been examined, but little is known about the consequences of such inhibition on the expression of isoprenylated G proteins. Holstein et al. [1] have now discovered that mevalonate depletion causes an upregulation of different Ras-related proteins.
Published Version
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