Abstract
A new look at old compounds
Highlights
Aging is the single most important risk factor in human disease in developed countries but when it comes to research on prevention or cures, aging is seldom taken into account
In concert with the stress response transcription factor, Heat Shock Factor 1 (HSF-1), DAF-16 regulates the formation of toxic protein aggregation, reduces the sensitivity to stress and increases lifespan in C. elegans [2, 3]
We addressed this issue by identifying small molecules able to slow protein aggregation in the C. elegans model
Summary
Aging is the single most important risk factor in human disease in developed countries but when it comes to research on prevention or cures, aging is seldom taken into account. In concert with the stress response transcription factor, Heat Shock Factor 1 (HSF-1), DAF-16 regulates the formation of toxic protein aggregation, reduces the sensitivity to stress and increases lifespan in C. elegans [2, 3]. Protein aggregation is a hallmark of aging and several age-related pathologies, collectively known as conformational diseases (CD) [4].
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