Abstract
Summary This new in vitro wound model consists of layers of human keratinocytes grown on a very thin transparent silicone disc in which a central hole is cut before placing it on a layer of collagen gel containing human fibroblasts (simulating a dermis). The growth of epidermal keratinocytes across the ‘wound' can easily be visualised and photographed by inverted light microscopy, at frequent intervals, to monitor the stimulating or adverse effect of many substances presently designed for wound treatment.
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