Abstract
Graphical Gastric ulcer is a very common gastrointestinal disorder affecting a large number of people worldwide. It arises due to an imbalance between aggressive (acid, pepsin and Helicobacter pylori infection) and protective (mucin secretion, prostaglandin, epidermal growth factors and bicarbonate) factors in the stomach. In this study, the gastroprotective activity has been investigated of the active constituents from Xylocarpus molluccensis. Antiulcer activity of xyloccensins X+Y was investigated and found to be active in various ulcer models in Sprague–Dawley (SD) rats. To understand the mechanism of action of active constituent of natural products, the effects of the compounds on antisecretory and cytoprotective activities were studied. Air dried fruits were extracted with ethanol and fractionated into four fractions. Xyloccensins X+Y were isolated from the active fraction and was tested against different ulcer models. Xyloccensins X+Y were found to possess anti-ulcerogenic activity. The antiulcer activity might be due to its anti-secretory activity and subsequent strengthening of the defensive mechanism. The present study has helped us in identifying a new lead in the form of xyloccensins that could be exploited in the treatment of gastric ulcer disease.
Highlights
Gastric ulcer is a very common gastrointestinal disorder affecting a large number of people worldwide
It arises due to an imbalance between aggressive and protective factors in the stomach
Xyloccensins X?Y were isolated from the active fraction and was tested against different ulcer models
Summary
Gastric ulcer is a very common gastrointestinal disorder affecting a large number of people worldwide. V. Lakshmi Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, UP, India. Palit Division of Pharmacology, Central Drug Research Institute, Lucknow 226001, UP, India bicarbonate) factors in the stomach [1]. Proton pump inhibitors, and histamine H2 receptor antagonists are commonly used drugs [3, 4]. Beside their therapeutic efficacies, several incidences of relapse, adverse effects and drug interactions have been shown to be associated with these drugs [5]. As a part of anti-ulcer drug discovery programs of our lab several Indian medicinal plants including Terminalia chebula [6] Xylocarpus granatum [7] and Nyctanthus arboritristis [8] have been reported to possess anti-ulcer activity. Keeping in consideration the above facts, we have selected this plant to determine its potential effects on gastric ulcer
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