Abstract
Gastric ulcer disease (GUD) is one of the major gastrointestinal disorders which occur due to an imbalance between offensive (acid, pepsin and Helicobacter pylori) and defensive (mucin, prostaglandin and bicarbonate) factors. Objective: The present study was to evaluate the ethanol extract of the Parmelia perlata (Huds.) Ach. (family Parmeliaceae) the gastroprotective activity against the cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Materials and methods: Adult Sprague Dawley rats of either sex, weighing 180-200g were housed in raised bottom mesh cages to prevent coprophagy and were kept in environmentally controlled rooms (25 + 2°C, 12 hours light and dark cycle). Results and conclusion: Potential anti-ulcer activity of the ethanol extract of the P. perlata was observed against CRU (50.0%), AS (37.5%), AL (65.41%) and PL (50.00%) induced ulcer models. The reference drug omeprazole (10mg/kg, p.o.) showed 77.40% protection against CRU and 57.08% against AS and 69.42% against PL model. Sucralfate, another reference drug (500 mg/kg, p.o.) showed 62.50% protection in AL induced ulcer model. The ethanol extract of the P. perlata reduced free acidity (19.04%), total acidity (14.43%) and upregulated mucin secretion by 14.17% respectively. Conclusion: The ethanolic extract of the P. perlata was found to possess anti-ulcerogenic activity which might be due to its secretary activity and subsequent strengthening of the defensive mechanism.
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