Abstract
Out of a number of compounds tested for cardiovascular activity, 2-imino-1, 3-diaza-4-carboxyethyl cycloheptane hydrochloride (OG 30) was found to produce an increase in blood pressure and a contraction of the nictitating membrane in cats. The above effects elicited by i.v.-administered OG 30 were either blocked or reduced by phentolamine, hexamethonium, guanethidine, N-N-diisopropyl-N′-isoamyl-N′-diethylaminoethyl urea hydrochloride (P-286), reserpinization and bilateral sympathectomy, but were not appreciably affected by cocaine, hemicholinium, atropine, spinal section or bilateral adrenalectomy. Thus it must be inferred that the compound caused a release of catecholamines largely by stimulation of the sympathetic ganglia. Ganglion-stimulating action was confirmed when the compound was injected directly to the superior cervical ganglion. The stimulant action on the parasympathetic ganglia though weaker, was also observed in dogs and in isolated guinea pig ileum. Hemicholinium was unable to block the contraction of the cat nictitating membrane in response to OG 30 and 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) administered directly to the superior cervical ganglion at a time when it had blocked the contraction of the membrane elicited by preganglionic sympathetic nerve stimulation. This observation conflicts with the participation of cholinergic link in the postganglionic adrenergic transmission in the nictitating membrane. OG 30 DMPP Ganglion-stimulation Adrenergic transmission Nictitating membrane Hemicholinium
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call