Abstract
A new exciton-coupled circular dichroism (ECCD) method is described for the configurational assignment of α- and β-hydroxy carboxylic acids. Using the chromophoric combination 2-naphthoate/9-methylanthryl group, the absolute stereochemistry of α- and β-hydroxy carboxylic acids can be deduced easily from a single CD measurement. The developed microscale method is also useful for chiral amino acids and natural products containing carboxyl groups.
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