Abstract
A new strategy in exciton-coupled circular dichroism (ECCD) is described for the configurational assignment of α-hydroxy carboxylic acids. Using 9-anthryldiazomethane (4), carboxyl groups can be selectively derivatized with a chromophore suitable for exciton coupling. In combination with the 2-naphthoate chromophore linked to the α-hydroxy group, the absolute stereochemistry of α-hydroxy carboxylic acids can be easily deduced from a single CD measurement. The usefulness of the new method is demonstrated with a series of α-hydroxy acids with different side chains. The developed microscale method is also useful for chiral amino acids and natural products containing carboxyl groups or similar structural units.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
