A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor.

Ali Moghaddam,Hassan Ali Zamani,Hassan Karimi-Maleh

doi:10.3390/mi12040437

Ali Moghaddam, Hassan Ali Zamani + Show 1 more

Open Access

https://doi.org/10.3390/mi12040437

Copy DOI

Abstract

A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe3O4-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF4−). The new platform showed a linear dynamic range from 0.001–220 µM with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, Fe3O4-SWCNTs/mim-BF4−/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, Fe3O4-SWCNTs/mim-BF4−/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58–103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples.

Highlights

Cancer is a major global problem and the cause of many deaths
SWCNTs-COOH, 1-hexyl-3-methylimidazolium tetrafluoroborate, graphite powder, ferric chloride, sodium hydroxide, phosphoric acid, iron (I) sulfate were purchased in analytical grade from Merck and Sigma-Aldrich Companies
transmission electron microscope (TEM) and field-emission scanning electron microscopy (FESEM) images of Fe3 O4 SWCNTs are shown in Figure 1A,B and the results clearly confirm the presence of Fe3 O4 nanoparticles with spherical shape and good distribution at the surface of single-wall carbon nanotubes

Summary

Introduction

Cancer is a major global problem and the cause of many deaths. Breast cancer is one of the most common and deadly cancers in women, and due to statistics, one in eightAmerican women will develop this cancer during their lifetime [1]. Taking too much DA can cause many side effects, such as bleeding, rash, and diarrhea in patients. Due to the high risk of using this drug, such as the increased risk of an infection that is relative to a drop in white blood cells, controlling the patient while taking this drug by a doctor or nurse is very important and necessary; using the appropriate judgment requires surveying its effect on the patient’s body which is impossible without using analytical methods [8,9]. Research has ensued to provide a fast, inexpensive, high-performance method to measure the important biological compounds [23,24,25,26,27,28,29]

Methods

Results

Conclusion