A New Asymmetric Synthesis of (R)- and (S)-3-Arylphthalides: Extremely High Diastereoselective Reaction of Arylcarbaldehydes with Chiral [2-(1,3-Oxazolidin-2-yl)phenyl]titanium Ate Complexes

Abstract

Chiral [2-(1,3-oxazolidin-2-yl)phenyl]titanium ate complexes are prepared from the corresponding lithium complexes, and the extremely high diastereoselective reaction or arylcarbaldehydes with the chiral titanium ate complexes is performed. Then, optically pure(R)-and (S)-3-arylphthalides are synthesized in favorable yields and the chiral auxiliary reagents are recovered with no less of the optical purity