Abstract
Uterine transplantation restores fertility in women with absolute uterine factor infertility and allows the opportunity to conceive, experience gestation, and acquire motherhood. The number of cases being performed is increasing dramatically, with detailed outcomes from 65 cases now available. Pregnancies achieved through uterus transplantation and following in vitro fertilization (IVF) are associated with an increased risk for further mother and newborn babies. This traditional review is focused on the safety and efficacy features of the treatment. However, it is associated with significant risk, with approximately one-quarter of grafts are removed because of complications. Uterine transplantation is realizable in women with uterine factor infertility but is associated with a significant complication risk. The risk of the procedure and gestational and delivery complications deserve important consideration before receiving such treatments. Nevertheless, these observations are preliminary and should be revised after a larger series of data are published.
Highlights
BackgroundHistorically, society believes that for girls to become "real mothers," they must carry a pregnancy themselves
Uterine transplantation is realizable in women with uterine factor infertility but is associated with a significant complication risk
Absolute uterine factor infertility (AUFI), which refers to infertility that is completely attributable to the uterine absence or an abnormality, affects approximately one in 500 women of childbearing age, or 1.5 million women worldwide [2]
Summary
BackgroundHistorically, society believes that for girls to become "real mothers," they must carry a pregnancy themselves. Absolute uterine factor infertility (AUFI), which refers to infertility that is completely attributable to the uterine absence (congenital or surgical) or an abnormality (anatomic or functional), affects approximately one in 500 women of childbearing age, or 1.5 million women worldwide [2]. Uterine factor infertility affects thousands of women worldwide, caused by congenital Müllerian malformations, such as in the MayerRokitansky-Küster-Hauser (MRKH) syndrome, or acquired as in the cases of women suffering from Asherman's syndrome, pregnancy-interfering myomas, or hysterectomies [2,3]. While a surrogacy agreement confers genetic motherhood and, after adoption, legal motherhood to infertile mothers. During this process, multiple medical and legal issues may arise. There is no legislation or regulation in other countries, leading to conflict between the involved parties [2]
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