Abstract

Addressing Infertility with Uterine Transplant

Highlights

  • The first live births via uterine transplant using deceased donors (UTx) occurred in Brazil in 20171 and in the United States in 2019.2 Prior to that, living donors were the source of uteruses for transplant, with the first successful birth in Sweden in 2014, and the first successful birth in the US in 2017

  • In the Middle East, adoption is uncommon because biological connections are crucial.[4]

  • By decreasing wait time, allowing living donors would provide the option of UTx while women are younger and more likely to achieve pregnancy since the in vitro fertilization (IVF) would be more likely to succeed increasing the chances that UTx would result in a child

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Summary

Permitting Living Donors or Limiting all UTx to Deceased Donors

The ethics of using a uterus from a deceased donor differs from using one from a living donor. Living kidney donations protect against kidney failure.[5] The uterine donor undergoes a four to eight-hour surgery to acquire the uterus for no potential health benefit to themselves or arguably, to the recipient.[6] UTx is not a life-saving procedure. That UTx with deceased donors has been successful, the ethical justification for continuing to allow living donation could be questioned. From the public health and ethical perspective, retrieving uteruses from deceased donors is a preferable option for the following reasons: First, there is no medical risk to the donor; public resources do not need to be allocated to resolving the potential complications from the procedure. By decreasing wait time, allowing living donors would provide the option of UTx while women are younger and more likely to achieve pregnancy since the IVF would be more likely to succeed increasing the chances that UTx would result in a child

Increased-Risk Donors
Potential Downsides of the Availability of Uterine Transplant
CONCLUSION
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