Abstract
A new method utilizing the graphical measurement of the length, ℓ above the occupancy time, Δt, of the minimum effective concentration was developed to aid in the quantification of the modified drug release of the sustained release formulations during the preformulation stages. Using simulated data, employing a conventional concentration/time plot in Cartesian coordinates, and expressing both parameters ℓ and Δt in units of distance, it was found that the ratio Δt ℓ is related to the rate of release of drug from the formulation. This enabled the evaluation of the extent to which drug release is modified by the formulation.
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