Abstract
Solvothermal reaction of 4,4’,4’-nitrilotribenzoic acid (H3TCA) with Ca(NO3)2·4H2O and Cd(NO3)2·4H2O successfully afforded a heterometallic compound, that is, [Cd2Ca(TCA)2(DMA)2(H2O)3]n·2n(DMA) (1, DMA = N,N’-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1’s luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1β content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA).
Highlights
Ischemic cerebral infarction refers to the degeneration, necrosis, or transient loss of function of the local brain tissue including nerve cells, glial cells, and connecting fibers due to blood supply disorders [1]
The biological activity of the new compound was evaluated, and the related mechanism was explored as well. e results of the real-time PCR indicated that the expression level of the hypersensitivity C-reactive protein (hs-CRP) expression in human brain microvascular endothelial cell (HBMEC) was significantly reduced by the new compound
Was reduced by the new compound, which was measured by the enzyme-linked immunosorbent assay (ELISA) assay
Summary
Ischemic cerebral infarction refers to the degeneration, necrosis, or transient loss of function of the local brain tissue including nerve cells, glial cells, and connecting fibers due to blood supply disorders [1]. In the last several decades, a great deal of the coordination polymers (CPs) having fascinating topological skeletons have been triumphantly produced by the polydentate organic ligands and metal ions or polynuclear metal clusters, and these crystalline CPs show promising application properties, such as luminescence sensing, molecular recognition, gas storage/separation, and heterogeneous catalysis that have attracted tremendous interest for the development of new inorganic-organic hybrid materials [4,5,6,7,8] From these reports, it can be found that the structure and properties of CPs are intimately related with the selected organic ligands. The IL-1β and IL-18 content released by HBMEC was reduced by the new compound, which was measured by the ELISA assay
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