Abstract
The global emergence of antimicrobial resistance poses a serious risk to patients by increasing the cost of healthcare with prolonged stay in hospitals, serious clinical complications, and even death. The ever-increasing challenges in discovering antibacterial agents with novel mechanisms of action necessitates the development of smart antibacterial surfaces that have the potential to minimize colonization of common hospital surfaces with bacterial pathogens. In this work, we report the antibacterial properties of flexible poly(dimethylsiloxane) (PDMS) polymer decorated with copper hydroxide nanowires (PDMS_Cu) against a panel of drug-resistant bacterial pathogens isolated from patients with bloodstream infection. The fabricated PDMS_Cu surface showed superior antimicrobial activity against both Gram negative (Escherichia coli and Klebsiella pneumoniae) and Gram positive (Staphylococcus aureus) bacterial strains as compared to flat PDMS and glass coverslip, which were used as controls. RAW macrophage and ...
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