Abstract
In the current study, we compared the effects of passive (bicycle) and active (treadmill) exercise combined with an electrospun crocetin-loaded neural conduits on sciatic nerve repair in a rat model. The animals were treated with a nanofibrous neural conduit and received regular excesses. Study showed that the animals treated with both exercise and neural conduits had significantly higher SFI values and better response to painful stimulus. In addition, gastrocnemius muscle re-innervation was significantly better in the crocetin-loaded conduits+exercise group.
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