Abstract
BackgroundAtopic dermatitis (AD) is characterized by chronic inflammation of the skin. AD develops mainly in infants and young children. It induces skin disorders and signals the initiation of the allergic march including allergic asthma and rhinitis. Probiotics modify intestinal microbial populations in a beneficial way for human and animal hosts by reducing inflammatory cytokines.ObjectiveAs a result of their immunomodulatory properties, probiotics have been considered a promising therapeutic option for the prevention and treatment of AD.DesignIn this study, we examined the effects of GI7, a potential probiotic mixture consisting of seven strains of bifidobacteria and lactic acid bacteria, on AD in a mouse model.ResultsAdministration of GI7 for 8 weeks reduced AD-like skin lesions and induced changes in the levels of serum markers such as immunoglobulin E and cytokines related to T helper (Th)1 and Th2 cells, and in skin barrier genes. Alleviation of AD seems to be associated with GI7-induced generation of CD4+Foxp3+ regulatory T cells.ConclusionsThe probiotic mixture may have potential to improve symptoms of AD.
Highlights
Atopic dermatitis (AD) is characterized by chronic inflammation of the skin
We investigated whether GI7 has potential therapeutic effects on AD-like skin lesions by using a 2,4-dinitrochlorobenzene (DNCB)Áinduced mouse model
The GI7-H group showed a steady decrease in dermatitis score; this decrease began to be significantly different from week 9 compared with that of the excipient and GI7-L groups
Summary
AD develops mainly in infants and young children. It induces skin disorders and signals the initiation of the allergic march including allergic asthma and rhinitis. Probiotics modify intestinal microbial populations in a beneficial way for human and animal hosts by reducing inflammatory cytokines. Design: In this study, we examined the effects of GI7, a potential probiotic mixture consisting of seven strains of bifidobacteria and lactic acid bacteria, on AD in a mouse model. Results: Administration of GI7 for 8 weeks reduced AD-like skin lesions and induced changes in the levels of serum markers such as immunoglobulin E and cytokines related to T helper (Th) and Th2 cells, and in skin barrier genes. Conclusions: The probiotic mixture may have potential to improve symptoms of AD
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