Abstract
Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide. Patient survival can be greatly improved if cancerous lesions are detected early. 1 Siegel R.L. et al. CA Cancer J Clin. 2020; 70: 7-30 Crossref PubMed Scopus (10742) Google Scholar Despite a strong recommendation of colonoscopy for CRC screening, patients prefer noninvasive tests, and 83% favor blood-based tests. 2 Adler A. et al. BMC Gastroenterol. 2014; 14: 183 Crossref PubMed Scopus (109) Google Scholar Blood tests that rely on a single DNA methylation biomarker have been approved 3 deVos T. et al. Clin Chem. 2009; 55: 1337-13346 Crossref PubMed Scopus (391) Google Scholar ; however, they are not recommended due to the low sensitivity for detecting early-stage CRC. 4 US Preventive Services Task Force et al. JAMA. 2016; 315: 2564-2575 Crossref PubMed Scopus (1196) Google Scholar
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