Abstract
Human papillomavirus (HPV) is the most common sexually transmitted infection in the US. HPV vaccine is a viable source of prevention against high-risk strains that are likely to cause cancer. However, particularly among racial and ethnic minorities such as Chinese Americans, HPV vaccination rates are suboptimal. The goal of this study was to evaluate the effect of a culturally tailored intervention on HPV vaccine uptake in Chinese Americans. We designed and implemented a multilevel longitudinal pilot study to examine the efficacy of the HPV intervention among Chinese American parents/guardians. We recruited 180 participants from federally qualified health center and community-based clinics that serve predominantly low-income Chinese Americans in Philadelphia. Participants were randomized into an intervention group (n = 110) or a control group (n = 70). The intervention group received an HPV specific intervention, while the control group received a general health intervention. The primary outcome was medical record-confirmed receipt of first shot and completion of HPV vaccine within six months of receiving the interventions. Repeated measure ANOVA was utilized to examine the intervention effect on knowledge between intervention and control groups. Knowledge differed significantly, with participants in the intervention group demonstrating the greatest improvement following the intervention. A multivariable logistic regression was used to examine the association between HPV vaccine initiation and study group assignment. There was a significant effect of provider recommendation, parent’s gender, and health insurance status on HPV vaccine uptake. This study demonstrated positive impact of a culturally tailored intervention on HPV vaccination uptake among Chinese Americans.
Highlights
In the United States, human papillomavirus (HPV) is the most common sexually transmitted infection (STI), affecting an estimated 79 million Americans [1]
We designed and conducted a longitudinal pilot study to evaluate the efficacy of an HPV vaccination intervention among Chinese American parents and guardians of teenagers
We examined the changes in mean HPV knowledge scores from baseline to post-intervention, by study group
Summary
In the United States, human papillomavirus (HPV) is the most common sexually transmitted infection (STI), affecting an estimated 79 million Americans [1]. Each year there are an estimated 14 million new cases of HPV in the United States [2]. HPV is most prevalent among teenagers and young adults [1]. It is associated with genital warts and various forms of cancer, such as cervical, penile, and oropharyngeal cancer [3]. The estimated incidence of cancers related to HPV is 19,400 for women and 12,100 for men [1, 3, 4]. Among these malignancies, cervical cancer (CC) is the most common. For CC the incidence rate in the United States is 8 cases per 100,000 persons [5]
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