Abstract
A genomics based approach has been used to identify members of the lysophosphatidic acid acyltransferase (LPAAT) multigene family in Arabidopsis thaliana. Ten putative members of this family containing conserved motifs known to be present in LPAAT and in glycerol-3-phosphate acyltransferase (GPAT) proteins have been identified in the Arabidopsis thaliana genome. These acyltransferases were classified according to their sequence similarity. A member of the first class of genes encodes a LPAAT implicated in glycerolipid biosynthesis in the eukaryotic pathway. The second class contains a gene that encodes an LPAAT of the prokaryotic pathway of lipid biosynthesis in plastids. An additional class containing three genes encodes proteins of unknown function previously undescribed as acyltransferases. The sequence divergence, compartmentalisation and differential expression of members of the gene family are consistent with a specific role for each LPAAT isoform in the production of phosphatidic acid.
Published Version
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