A multi-period multi-objective closed-loop blood supply chain configuration and optimisation under disruption

Abstract

The COVID-19 pandemic has highlighted the stability of the blood supply chain in case of interruption and other emergencies. Blood is a precious and perishable substance, and any disruption in its supply can cause serious consequences. Current research on the blood supply chain mostly focuses on a multi-objective perspective, and rarely involves both multi-objective and multi-period methods simultaneously. Therefore, we develop a multi-period multi-objective closed-loop blood supply chain model that considers disruptions and uncertainties of demand and recovery, aiming at achieving a balance among various objectives, and coordination of various periods. Fuzzy chance-constraint, meta-heuristic approaches and exact solution (CLPEX) are adopted to mitigate the impact of uncertainties and calculate the optimal solution of a calculating case. The calculation outcomes indicate that: With regard to economic costs and social benefit, the multi-period system is better than the single-period system; the comprehensive performance of the multi-target system is better than that of the single-target system; and the multi-period multi-objective system is more in line with the real situation. Meanwhile, the mitigation strategies, such as maintaining emergency inventory and implementing lateral transshipment, can significantly enhance the performance of the system in disruptions. This paper mainly contributes the follows: Firstly, it provides a reference for configuration and optimisation of a cross-region closed-loop supply chain under disruptions and uncertainties. Secondly, the comprehensive trade-off of multi-objective and multi-period in this paper is especially suitable for perishable production with short cycles, large fluctuations of supply and demand.