Abstract
AbstractGastrin cells of the antral mucosa of the dog were studied with electron microscopy and morphometric techniques before and after 1 hour of stimulation with bile. Control cells exhibited specific gastrin granules with a very electron‐dense core and some granules containing few or no secretory product. After 1 hour of bile stimulation, the volume density of the granular population was not different from the control, but the number of granules increased, their mean dimensions decreased, and the amount of secretory product was also significantly decreased. It is concluded that bile is an effective stimulus of gastrin secretion. Gastrin is released into the cytoplasm and there is some delay in the utilization of the granular membranes, so that an increase in the number of granules after continuous stimulation was observed. Under these conditions the mean diameter of the granular population is smaller than in control cells probably because there is a newly formed granular population which releases its secretory content under continuous stimulation before attaining the usual dimensions.
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