Abstract
In this brief review, we will present evidence that platelet endothelial cell adhesion molecule-1 (PECAM-1) is a mechanoresponsive molecule. When endothelial cells (ECs) are exposed to mechanical stress, PECAM-1 is tyrosine-phosphorylated and recruits SHP-2 and Gab1 to the area of cell–cell attachment. These events are necessary for ERK activation by fluid shear stress (FSS) and cyclic stretch in endothelial cells. Both PECAM-1 tyrosine phosphorylation and ERK activation can be achieved by applying mechanical force directly on PECAM-1, suggesting that PECAM-1 is a mechanotransduction molecule.
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