Abstract
The efficacy of a miniaturized unimolecular analytic system is illustrated. The easily accessible therapeutic chromophore “temoporfin”, which responds differentially to bound metals at multiple wavelengths of Q-band absorption using chemometric analysis, expeditiously detects and discriminates a wide range of metals regarded as priority pollutants in water and hence may also be used for diagnosis of medically relevant metals in human urine. The molecule was further investigated as an electronic logic device, e.g. keypad lock device, to authorize multiple highly secure chemical passwords for information protection.
Highlights
The designing of analytical systems to sense multianalytes at the molecular level[1,2,3,4,5] and exploiting them as computational devices to mimic logic gates and circuits[6,7,8,9,10,11,12,13] has attracted special attention in the last decades
We describe a miniaturized analytical system consisting of a single universal “receptor-cum-reporter”, temoporfin (1), which is an accessible therapeutic chromophore and which responds differentially to bound metal ions at multiple wavelengths of Q-band absorption across the far visible to near IR region (500–700 nm)
The potential of temoporfin was further investigated as a 2-digit electronic keypad lock device to create highly secure multiple chemical passwords for information protection
Summary
The spectral characteristics of the metalloporphyrin is governed primarily by the size and position of metal ions with respect to the cavity of the ligand (as anticipated by Barnes and Dorough)[69] and secondly, with the electronic structure of the metal centers (as proposed by Gouterman)[70,71]. The steric effects of meso substitution, the influence of size and charge of metal ions on binding cooperativity, the extent of axial M-OH bonding and aggregation in the analytical media increase the conformational dynamics of metallochlorin This structural change results in unsymmetrical vibrations along the X- and Y-axis of sensor which can be utilize for the generation of distinct analyte-specific Q-band spectral signatures. This was demonstrated by addition of each metal (M0 or M1), followed by a second addition of the same input signal generates different absorption pattern for M0M0 or M1M1 code entries (Fig. 7a). These chemical passwords are doubly protected and unbreakable as they adopt both the principle of electronic digital locking and biometric pattern locking
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