Abstract
The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors. On the other hand, it has been reported that the incorporation of a metal ion into coumarin derivatives can increase the activity of such complexes compared to coumarin-based ligands. Accordingly, some of them have been found to display promising antioxidant, antitumor or antibacterial activities. This mini-review briefly summarizes the recent development of coumarin-metal complexes with proven biological properties. The attention is also paid to agents for which practical applications in the detection of biologically important species may be found.
Highlights
Coumarins belong to a family of large and extensively studied compounds containing 2H-1benzopyran-2-one core structure, which consists of fused benzene and α-pyrone rings
The kinetic studies of enzymatic activity revealed that copper (II) complex was more effective than manganese (II) one and both complexes possess better catecholase-like activity than phenoxazinone synthase mimetic properties, These results indicate that complexes 52 and 53 represent a good starting point for the design of promising tools for the catecholase-like and phenoxazinone synthase-like activities
The considerable increase in the number of papers and reports describing the possible uses of coumarin-based metal complexes in therapy and medicine is a vivid demonstration of their impact on the scientific community
Summary
The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, antiinflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors. It has been reported that the incorporation of a metal ion into coumarin derivatives can increase the activity of such complexes compared to coumarin-based ligands. Some of them have been found to display promising antioxidant, antitumor or antibacterial activities. This mini-review briefly summarizes the recent development of coumarin-metal complexes with proven biological properties. The attention is paid to agents for which practical applications in the detection of biologically important species may be found
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