Abstract
The dose enhancement due to the 10B thermal neutron capture reaction in a fast neutron therapy beam of mean energy 20.4 MeV has been measured using a microdosimetric technique with paired Rossi tissue-equivalent-plastic proportional counters. The enhancement in a simulated tissue volume of 2 mu m diameter for a concentration of 50 ppm of 10B has been measured in 10 cm*10 cm and 15 cm*15 cm fields at various depths in a water phantom. The physical dose enhancement due to the high LET alpha particles and Li recoil ions ranges from approximately 1% to approximately 2% depending on the depth and field size. Correction factors for the absence of 10B in the counter gas and for the RBE advantage of the enhanced dose have been estimated to be*1.25 and*2, respectively. The total dose enhancement using these factors ranges from approximately 2.5% to approximately 5%.
Published Version
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