Abstract
Breast cancer is the most common carcinoma in women. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effect and resistance against anticancer drugs. Complementary and alternative medicine (CAM) may avoid these problems, in which traditional Chinese medicine (TCM) has been highlighted. In this section, to analyze the mechanism through which TCM act on breast cancer, we have built a virtual model consisting of the construction of database, oral bioavailability prediction, drug-likeness evaluation, target prediction, network construction. The 20 commonly employed herbs for the treatment of breast cancer were used as a database to carry out research. As a result, 150 ingredient compounds were screened out as active molecules for the herbs, with 33 target proteins predicted. Our analysis indicates that these herbs 1) takes a ‘Jun-Chen-Zuo-Shi” as rule of prescription, 2) which function mainly through perturbing three pathways involving the epidermal growth factor receptor, estrogen receptor, and inflammatory pathways, to 3) display the breast cancer-related anti-estrogen, anti-inflammatory, regulation of cell metabolism and proliferation activities. To sum it up, by providing a novel in silico strategy for investigation of the botanical drugs, this work may be of some help for understanding the action mechanisms of herbal medicines and for discovery of new drugs from plants.
Highlights
Over about one million people would have been diagnosed with cancer and 600,000 will have died of cancer during 2004 in the United States [1]
It is assumed that Radix Salviae as monarch herbal medicine plays a principal role in therapeutic effect
This discipline is practiced worldwide that Traditional Chinese Medicine (TCM) may serve as a useful model for scientific inquiry since there is a standardized system of diagnostics and therapies
Summary
Over about one million people would have been diagnosed with cancer and 600,000 will have died of cancer during 2004 in the United States [1]. The widespread use of a variety of nutritional, psychological and natural medical approaches, collectively-termed complementary and alternative medicine (CAM), has been well documented It is defined as methods used in the diagnosis, treatment, or prevention of disease that complement mainstream medicine, as opposed to alternative therapies, which are used as a direct substitute for mainstream medicine [3]. The United States National Cancer Institute (NCI) has a long history demonstrating its interest in the scientific evaluation of complementary [4]. It supports CAM research which includes different methods and practices and other medical systems especially herb medicine [4]. Because of their extensive use and the therapeutic effects, there is an increasing interest and need to develop new methods for understanding of herb medicine, including the identification of active ingredients and their targets in the context of molecular network
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