Abstract
We read with great interest a study by Golledge et al 1 Golledge J. van Bockxmeer F. Jamrozik K. McCann M. Norman P.E. Association between serum lipoproteins and abdominal aortic aneurysm. Am J Cardiol. 2010; 105: 1480-1484 Abstract Full Text Full Text PDF PubMed Scopus (72) Google Scholar demonstrating no association between serum low-density lipoprotein (LDL) concentrations and abdominal aortic aneurysm (AAA) but a consistent association between low serum high-density lipoprotein (HDL) concentrations and the presence of a small AAAs in a large population prone to aortic dilation (i.e., men aged ≥65 years). Although a number of studies compared serum HDL or LDL concentrations between patients with AAAs and control subjects, no meta-analysis has been conducted to date to the best of our knowledge. To summarize the present evidence for an association between serum HDL or LDL concentrations and AAA presence, we herein report a meta-analysis of studies from which we can abstract mean and SD serum HDL or LDL concentrations. Association Between Serum Lipoproteins and Abdominal Aortic AneurysmAmerican Journal of CardiologyVol. 105Issue 10PreviewThe importance of dyslipidemia in the etiology of abdominal aortic aneurysm (AAA) is poorly defined, in part because previous association analyses have often not considered the use of current lipid-modifying medications. Medications targeted at altering the concentrations of circulating lipids have an established role in occlusive atherosclerosis but are of unknown value in the primary prevention of AAA. We examined the association between fasting serum levels of triglycerides low- and high-density lipoprotein and the presence of an AAA in a cohort of 3,327 men aged 65 to 83 years. Full-Text PDF
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