Abstract
Objective To investigate whether sulfonylurea(SU)increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT)was performed to compare the risk of stroke between type 2 diabetic patients treated with SUs and comparators. Results 1 612 articles were retrieved, and finally 17 articles were included. Patients receiving SUs treatment had a higher relative risk of stroke(RR 1.35, 95%CI 1.13-1.60)than those who received comparators. The I2 statistic for heterogeneity between 17 trails was 0.0%(P=0.687). No major asymmetry appeared in the funnel plot and Begg' adjusted rank correlation test(kendall's score=22, P=0.387). Conclusion The use of SUs may raise the risk of stroke which is already high in patients with T2DM.(Chin J Endocrinol Metab, 2015, 31: 758-764) Key words: Diabetes mellitus, type 2; Stroke; Sulfonylureas; Meta analysis
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