A meta-analysis of oral preparation of ginkgo biloba in treating vascular dementia

Abstract

Objective To systematically evaluate the efficacy and safety of oral preparation of ginkgo biloba in treating vascular dementia (VD). Methods A fully literature search was conducted in CNKI, Wanfang, Sinomed, VIP databases, PubMed, Embase, the Cochrane Library and Clinical Trails with the deadline of October, 2018 for randomly controlled trials of oral preparation of ginkgo biloba for vascular dementia. After assessing the quality of literatures included, RevMan5.3 software was used to analyze the extracted data. Results A total of 17 studies which including 1 326 patients were involved. The results of meta-analysis showed that: compared with the western medicine group, oral ginkgo biloba preparation combined with western medicine group was much better in the MMSE assessment [MD=2.89, 95% CI (2.06, -3.72), P=0.000 1], there was no significant difference between the western medicine group and the pure oral ginkgo biloba group in the ADL assessment [MD=-3.00, 95% CI (-4.69, -1.30), P=0.000 5] and overall clinical status assessment [RR=1.29, 95% CI (1.20,1.39), P<0.000 01], the efficacy of the pure oral ginkgo biloba group and western medicine group was similar in the ADL assessment [MD=-0.93, 95% CI (-3.48, 1.63), P=0.48]. Conclusions Based on the meta-analysis, oral preparation of ginkgo biloba combinedwithwesternmedicinehas certain advantages compared with conventional western medicine treatment alone, but a large number of large-sample and high-quality trials are requiredtofurther prove and review its effect. Key words: Dementia, vascular; Preparation of ginkgo biloba; Meta-analysis; Systematic review